Enfermades raras y extrañas|Enfermedades y Sindromes

Amplio resumen de las enfermedades y sindromes más raras que existen en nuestro planeta.

miércoles, 4 de septiembre de 2013

Enfermades raras y extrañas

Enfermades raras y extrañas


Prevenir la Ceguera y Deficiencias visuales

Posted: 04 Sep 2013 11:20 AM PDT

Prevenir la Ceguera y Deficiencias visuales


RETINOSIS PIGMENTARIA Y LA MIRA EN LA CELULAS MADRE

Posted: 03 Sep 2013 08:30 PM PDT

La ceguera hereditaria abarca un amplio espectro de patologías que pueden ser causadas por mutaciones en más de 220 genes. La Retinosis pigmentaria es una de las formas más comunes de los 250 tipos hereditarios conocidos y se caracteriza por disminuir progresivamente la visión debido a la muerte de las células dentro de la retina.
Ocurre en dos formas genéticas llamadas dominantes y recesivas y resultan en cientos de mutaciones distintas dentro de decenas de genes.
Aunque algunos tratamientos están disponibles, el alto nivel de la idiosincrasia asociada a la condición ha llevado a los investigadores a concluir que enfoques basados en células madres podrían ofrecer la mejor esperanza para la cura.
 
Para explorar la posibilidad de tratar la ceguera hereditaria con células madre, Edwin Stone y sus colaboradores en la Universidad de Iowa analizaron rutinariamente la pantalla de ADN de individuos que experimentan pérdida de la visión para identificar las mutaciones genéticas que conducen a su ceguera; el equipo de Iowa también generó células madre pluripotentes inducidas (iPSCs) de estos individuos para crear modelos específicos del paciente de la enfermedad.
Ahora, , Stone y su equipo — incluyendo Budd Tucker como primer autor — informan que usaron tecnología de células madre para crear un modelo personalizado de una forma recesiva de la retinosis pigmentaria, y que tienen también éxito al ser trasplantadas dichas células en ratones (Tucker et al., 2013).
Estos resultados son un paso importante hacia el trasplante autólogo, la regeneración de los tejidos dañados por la enfermedad utilizando células madre derivadas de las propias células del paciente (Figura 1).
Además de beneficiar a la investigación básica, estos resultados representan un medio para desarrollar la comprensión específica de tratamiento para una variedad de condiciones genéticas — en particular, el gran conjunto de síndromesque causan la ceguera hereditaria.
Figure 1.
Figura 1.
Una nueva estrategia para el trasplante autólogo de células para tratar la ceguera hereditaria.
Una biopsia de la piel de un paciente con retinitis pigmentosa — una forma hereditaria de la ceguera que resulte de la pérdida de células fotorreceptoras en la retina — se utiliza para aislar los queratinocitos que luego se reprograman en células madre pluripotentes inducidas (iPSCs). Los iPSCs son estimulados para diferenciarse en precursores de células fotorreceptoras en una placa Petri. Estas células fotorreceptoras inmaduras pueden ser evaluadas en el estudio para identificar los defectos que dieron lugar a la ceguera del paciente. Trasplante acertado es seguido por la maduración del fotorreceptor y la restauración de la visión funcional.
 
Las primeras células iPSCs se generaron en 2007 reprogramando células humanas de fibroblastos aislados de la piel y se demostró que eran muy parecidas a las células madre embrionarias (Takahashi et al., 2007; Yu et al., 2007).
 
La característica más importante de iPSCs y las células madre embrionarias es que son "pluripotentes": en otras palabras, ellas tienen la capacidad de diferenciarse en muchos tipos de distintas células maduras que normalmente se encuentran en el cuerpo.
 
Desde las iPSCs pueden ser creados por la reprogramación de las células de los adultos (en contraposición a las células madre embrionarias, que, como su nombre indica, se obtienen de embriones en desarrollo), que proporcionan un medio para modelar precisamente la enfermedad genética de un individuo.
 
Las iPSCs también pueden allanar el camino hacia la terapia génica. Por ejemplo, células de la retina pueden ser generadas en la cultura de iPSCs derivadas del paciente y utilizadas para estudiar si la introducción de genes específicos en estas células puede compensar un defecto en su función biológica.
 
Además, las mutaciones que causan las enfermedades pueden corregirse fuera del cuerpo del paciente mediante la 'edición' del ADN que hay dentro de las células y las células corregidas se puede volver a diferenciar para formar el tipo de célula destruida por la enfermedad.
En última instancia, los investigadores esperan ser capaces de introducir genes específicos o células saludables, maduras derivadas de iPSCs en un tejido enfermo para restaurar la función normal.
 
 
El equipo de Iowa ahora ha progresado hacia la comprensión y quizás incluso poder tratar, una forma de un retinosis pigmentaria autosómica recesiva. El estudio involucró a un varón de 62 años ciego.
El primer paso fue identificar las mutaciones que causan la enfermedad; Estas mutaciones fueron encontradas en USH2A, un gen que previamente se ha asociado con el síndrome de Usher, que causa ceguera y sordera. Se identificaron mutaciones en ambos alelos del gen, incluyendo uno en una región no codificante, según informaron recientemente otros investigadores (Vache et al., 2012).
 
 
Stone y sus colaboradores generaron  iPSCs desde las células tomadas de la piel del paciente. Al estimular estas iPSCs para diferenciación, fueron capaces de obtener distintos tipos de células retinianas según informan otros (Meyer et al., 2011; Rowland et al., 2012), y además las células forman estructuras similares a retina 'ojeras'. Inicialmente estas ojeras contuvieron el epitelio pigmentario de la retina, un tejido que suministra nutrientes a los fotorreceptores.
Con el tiempo, las células fotorreceptoras también comenzaron a desarrollar; Estas células fueron identificadas por la presencia de la rodopsina, un pigmento visual, así como diversas características estructurales.
Lo importante, los tejidos derivados de iPSC del paciente ofrecieron un modelo para el inicio del tratamiento de la retinosis pigmentaria del paciente: mientras que las mutaciones no deterioran el desarrollo de las ojeras en el estudio, la proteína mutada USH2A estaba mal, lo que resultaba en un estrés celular que probablemente causó la muerte de los fotorreceptores, y por lo tanto ceguera.
 
Si las células cultivadas in vitro pueden colonizar un tejido en vivo serán cruciales para la aplicación médica de este trabajo. Para evaluar cómo sus células derivadas de iPSC irían en tejido vivo, el equipo de Iowa trasplanta las células fotorreceptoras inmaduras en el ojo de un ratón.
Dentro de dos semanas estas células se habían integrado en la retina y habían diferenciado, lo que indica que este método podría también tener perspectivas favorables en pacientes humanos con ceguera hereditaria.
 
El flujo de trabajo descrito por Stone y compañeros de trabajo es particularmente notable dada la edad del paciente. Su éxito fue probablemente facilitado por la decisión de utilizar los queratinocitos de la biopsia de piel inicial, en lugar de otro tipo de célula encontrada en la piel, fibroblastos. Las células de las personas mayores son mucho más difíciles de programar que los de los más jóvenes, y es tanto más rápido y cien veces más eficiente para reprogramar los queratinocitos que los fibroblastos (Aasen et al., 2008).
El equipo de Iowa decidió trabajar con queratinocitos y desde ellos derivar del mismo tejido embrionario (ectodermo) a tejido retiniano, argumentando que la diferenciación de iPSCs en tejido retiniano puede facilitarse mediante el uso de células con un origen similar. Además, el derivado de queratinocitos iPSCs ha informado que se asemejan a las células madre embrionarias más que aquellas derivadas de los fibroblastos (Barrero et al., 2012) y prometedores modelos de formación ocular en tres dimensiones se han generado utilizando células madre embrionarias de humanos (Nakano et al., 2012) y de ratón (Eiraku et al., 2011; Gonzalez-Cordero et al., 2013).
 
En particular, las ojeras no se formaron en estudios anteriores donde estos investigadores utilizaron fibroblastos para hacer iPSCs.
 
La meta del equipo de Iowa es desarrollar una terapia específica de paciente utilizando células fotorreceptoras generadas a partir de iPSCs. En el caso de USH2A, la terapia génica para introducir una 'copia' del gen es probable que sea una mala solución, como la región codificante de este gen es demasiado grande para vectores de la terapia del gene retiniano establecido. Además, muchas de las células fotorreceptoras en la retina de este paciente particular ya habían muerto debido a la enfermedad y por lo tanto no podían responder a la terapia génica.
 
En casos como éste, el trasplante de la célula parece la estrategia más viable, y los resultados reportados por Stone y compañeros de trabajo después del trasplante de células inmaduras del fotorreceptor en ratones son prometedores.
Este paciente — y otros con mutaciones similares — podrían beneficiarse potencialmente en décadas si las células se lograsen integrar y diferenciar adecuadamente en su retina, ya que tenía visión razonable hasta su tercera década de vida. Podría resultar un efecto aún más duradero si una o ambas de las mutaciones USH2A del paciente fueran corregidos, antes del trasplante, con precursores del fotorreceptor derivados de iPSC utilizando enfoques de edición de genes.
 
Claramente se necesitarán muchos otros estudios antes de que este método puede ser probado en humanos, incluyendo la optimización de los parámetros para el trasplante; evaluación de la seguridad y la longevidad de las células trasplantadas; y demostración de la capacidad de las células trasplantadas para restaurar la visión adecuadamente.
Los estudios de Stone y compañeros de trabajo son, sin embargo, un paso emocionante y proporcionan las bases para nuevos enfoques para tratar la ceguera mediante modelos celulares personalizados.

Improve your Vision - Natural Gateways

Posted: 04 Sep 2013 10:20 AM PDT

Improve your Vision - Natural Gateways


It has been said the eyes are the windows to the soul, but they also our windows to look out and observe the world. Eyes are important for seeing things, reading, working, and even communicating. The eyes are sensitive though, they work hard and they need time to rest and recover from the constant strain put on them.

Did you know that we can cure poor eyesight just by changing a few bad habits? We are extremely hard on our eyes and taking to the time to practice relaxation exercising can help us see more clearly. Even if you have worn glasses for years or are prone to eye problems and eye disease, learning to take the strain and stress away from the eyes can cure all that.

Strain and stress are the main factors affecting poor eyesight. Everyone is born with relatively good eyesight. Throughout our school age years we are taught bad habits that cause our eyes to strain too much. Sitting in a classroom, constantly staring at a blackboard, books, or paper all day leaves our eyes tired and stressed. There is no time between classes or subjects to relax the eyes and give them a few moments of rest. These habits carry over to our adult lives and we do the same thing at work day in and day out.

The body gives out signals when it needs rest. If we spend too much time on household chores the backs starts to hurt and the arms get tired. These signals tell us to take a break, lie down, or just relax for few minutes. Likewise, they eyes can tell you when they need a break as well. The head may start hurting, the eyes start to burn a little, or a slight twitch may develop in one or both eyes. These are signs that the eyes need to rest.

Resting the eyes is as simple as finding a quiet place, relaxing the mind, and closing the eyes so they can re-energize. Bad eyesight doesn’t have to happen. We can take steps today to develop the habits that will increase our eyesight for the rest of our lives.

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The Importance of Physical Variability" in Cardio Exercise

Posted: 04 Sep 2013 09:36 AM PDT

The Importance of Physical "Variability" in Cardio Exercise

Your Cardio Workouts might not be serving to you unless you incorporate a high vary of rate shifts in your coaching


Are you a cardio junkie? everybody looks to suppose that "cardio" is that the best thanks to get in form and lose body fat. i am progressing to show you with this text why I disagree!


It is quite common to listen to fitness execs, doctors, and different health professionals dictate low to moderate intensity aerobic coaching (cardio) to those that are attempting to stop cardiopathy or slenderize. Most often, the recommendations go one thing like this:

"Perform 30-60 minutes of steady pace cardio 3-5 times/week maintaining your rate at a moderate level"

Before you simply surrender to the current fashionable belief and become the “hamster on the wheel” doing endless hours of boring cardio exercise, I’d such as you to contemplate some recent research that indicates that steady pace endurance cardio work might not be all it’s cracked up to be.

First, notice that our bodies area unit designed to perform physical activity in bursts of toil followed by recovery, or stop-and-go movement rather than steady state movement. Recent analysis is suggesting that "physical variability" is one amongst the foremost vital aspects to contemplate in your coaching.

This tendency may be seen throughout nature as most animals tend to demonstrate "stop-and-go" motion rather than steady state motion. In fact, humans area unit the sole creatures in nature that arrange to do “endurance” sort physical activities like running long distances at the precise same speed the full time.

Most competitive sports (with the exception of endurance running or cycling) are supported stop-and-go movement or short bursts of toil followed by recovery.

To examine Associate in Nursing example of the various effects of endurance or steady state coaching versus stop-and-go coaching, think about the physiques of marathoners versus sprinters. Most sprinters carry a physique that's terribly lean, muscular, and powerful trying, whereas the standard dedicated long-distance runner is a lot of usually skeletal and sickly trying. currently which might you rather resemble?
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Another issue to stay in mind relating to the advantages of physical variability is that the internal result of varied styles of exercise on our body. Scientists have identified that excessive steady state endurance exercise (different for everybody, however typically outlined as bigger than hr per session most days of the week) will increase atom production within the body, will degenerate joints, reduces immune operate, causes muscle wasting, and might cause a pro-inflammatory response within the body which will probably cause chronic diseases.

Highly variable cyclic coaching

On the opposite hand, extremely variable cyclic coaching has been joined to increased inhibitor production within the body Associate in Nursingd an medicament response, a a lot of economical gas response (which will encourage a healthy vessel system), Associate in Nursingd an increased rate response (which will assist with weight loss). what is more, steady state endurance coaching solely trains the guts at one specific rate vary and doesn’t train it to reply to numerous each day stressors.

On the opposite hand, extremely variable cyclic coaching teaches the guts to reply to and pass though a range of demands creating it less doubtless to fail after you want it. suppose it this fashion... Exercise that trains your heart to quickly increase and quickly decrease can create your heart a lot of capable of handling everyday stress. Stress will cause your pressure level and rate to extend quickly. Steady state cardiopulmonary exercise and different endurance coaching doesn't train your heart to be ready to handle speedy changes in rate or pressure level.

The vital facet of variable cyclic coaching that creates it superior over steady state cardio exercise is that the recovery amount in between bursts of toil. That recovery amount is crucially vital for the body to elicit a healthy response to Associate in Nursing exercise stimulant. Another good thing about variable cyclic coaching is that it's way more attention-grabbing and has lower drop-out rates than long boring steady state cardio programs.

To summarize, a number of the potential edges of variable cyclic coaching compared to steady state endurance coaching area unit as follows: improved vessel health, increased anti-oxidant protection, improved immune operate, reduced risk for joint wear and tear, increased muscularity (versus diminished muscularity with endurance training), increased residual rate following exercise, Associate in Nursingd an increased capability for the guts to handle life’s each day stressors.

Sports Workouts and Sprinting

There area unit some ways you'll be able to reap the advantages of stop-and-go or variable intensity physical coaching. best sports like soccer, basketball, volleyball, racquetball, tennis, hockey, baseball, etc. area unit naturally comprised of extremely variable stop-and-go motion that trains the guts through a far wider rate vary compared to merely steady walking or cardiopulmonary exercise.

Doing swimming workouts during a variable intensity fashion might also be a lot of helpful than simply swimming for an extended length at identical speed. Same goes for cycling -- that's why mountain biking, that involves extreme ups and downs at numerous intensity levels might also be a lot of helpful than simply an extended flat steady pace bike ride.

One of absolutely the only styles of variable intensity coaching to actually cut back body fat and convey out serious muscular definition is activity wind sprints. Wind sprints may be done by sprinting at close to goop speed for 10-30 seconds, and so taking sixty seconds to steer for recovery before your next sprint. 6-12 total sprint intervals is typically a really difficult sweat for many individuals.

In addition, weight coaching naturally incorporates short bursts of toil followed by recovery periods. High intensity interval coaching (varying between high and low intensity intervals on any piece of cardio equipment) is one more coaching methodology that utilizes toil and recovery periods. for instance, Associate in Nursing interval coaching session on the treadmill might look one thing like this:

Warm-up for 3-4 minutes at a quick walk or light-weight jog

Interval one - run at eight.0 mi/hr for one minute
Interval a pair of - walk at four.0 mi/hr for one.5 minutes
Interval three - run at ten.0 mi/hr for one minute
Interval four - walk at four.0 mi/hr for one.5 minutes

Repeat those four intervals four times for a really intense 20-minute sweat.

Also, do not overlook different nice ways in which to include variable intensity cardio coaching by employing a jump rope, a athletics machine, stairs running, or maybe out of doors hill sprints.


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The Importance of Physical "Variability" in Cardio Exercise

Posted: 04 Sep 2013 09:03 AM PDT

The Importance of Physical "Variability" in Cardio Exercise

Your Cardio Workouts may NOT be helping you unless you incorporate a high range of heart rate shifts in your training

Are you a cardio junkie? Everyone seems to think that "cardio" is the best way to get in shape and lose body fat. I'm going to show you with this article why I disagree!

It is quite common to hear fitness pros, doctors, and other health professionals prescribe low to moderate intensity aerobic training (cardio) to people who are trying to prevent heart disease or lose weight. Most often, the recommendations go something like this:


"Perform 30-60 minutes of steady pace cardio 3-5 times/week maintaining your heart rate at a moderate level"

Before you just give in to this popular belief and become the “hamster on the wheel” doing endless hours of boring cardio exercise, I’d like you to consider some recent scientific research that indicates that steady pace endurance cardio work may not be all it’s cracked up to be.

First, realize that our bodies are designed to perform physical activity in bursts of exertion followed by recovery, or stop-and-go movement instead of steady state movement. Recent research is suggesting that "physical variability" is one of THE most important aspects to consider in your training.

This tendency can be seen throughout nature as most animals tend to demonstrate "stop-and-go" motion instead of steady state motion. In fact, humans are the only creatures in nature that attempt to do “endurance” type physical activities such as running long distances at the exact same speed the whole time.

Most competitive sports (with the exception of endurance running or cycling) are also based on stop-and-go movement or short bursts of exertion followed by recovery.

To examine an example of the different effects of endurance or steady state training versus stop-and-go training, consider the physiques of marathoners versus sprinters. Most sprinters carry a physique that is very lean, muscular, and powerful looking, while the typical dedicated marathoner is more often emaciated and sickly looking. Now which would you rather resemble?

Another factor to keep in mind regarding the benefits of physical variability is the internal effect of various forms of exercise on our body. Scientists have known that excessive steady state endurance exercise (different for everyone, but sometimes defined as greater than 60 minutes per session most days of the week) increases free radical production in the body, can degenerate joints, reduces immune function, causes muscle wasting, and can cause a pro-inflammatory response in the body that can potentially lead to chronic diseases.

Highly variable cyclic training

On the other hand, highly variable cyclic training has been linked to increased antioxidant production in the body and an anti-inflammatory response, a more efficient nitric oxide response (which can encourage a healthy cardiovascular system), and an increased metabolic rate response (which can assist with weight loss). Furthermore, steady state endurance training only trains the heart at one specific heart rate range and doesn’t train it to respond to various every day stressors.

On the other hand, highly variable cyclic training teaches the heart to respond to and recover from a variety of demands making it less likely to fail when you need it. Think about it this way... Exercise that trains your heart to rapidly increase and rapidly decrease will make your heart more capable of handling everyday stress. Stress can cause your blood pressure and heart rate to increase rapidly. Steady state jogging and other endurance training does not train your heart to be able to handle rapid changes in heart rate or blood pressure.

The important aspect of variable cyclic training that makes it superior over steady state cardio exercise is the recovery period in between bursts of exertion. That recovery period is crucially important for the body to elicit a healthy response to an exercise stimulus. Another benefit of variable cyclic training is that it is much more interesting and has lower drop-out rates than long boring steady state cardio programs.

To summarize, some of the potential benefits of variable cyclic training compared to steady state endurance training are as follows: improved cardiovascular health, increased anti-oxidant protection, improved immune function, reduced risk for joint wear and tear, increased muscularity (versus decreased muscularity with endurance training), increased residual metabolic rate following exercise, and an increased capacity for the heart to handle life’s every day stressors.
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Sports Workouts and Sprinting

There are many ways you can reap the benefits of stop-and-go or variable intensity physical training. Most competitive sports such as football, basketball, volleyball, racquetball, tennis, hockey, baseball, etc. are naturally comprised of highly variable stop-and-go motion which trains the heart through a MUCH wider heart rate range compared to just steady walking or jogging.

Doing swimming workouts in a variable intensity fashion may also be more beneficial than just swimming for a long duration at the same speed. Same goes for bicycling -- that is why mountain biking, which involves extreme ups and downs at various intensity levels may also be more beneficial than just a long flat steady pace bike ride.

One of the absolute most effective forms of variable intensity training to really reduce body fat and bring out serious muscular definition is performing wind sprints. Wind sprints can be done by sprinting at near max speed for 10-30 seconds, and then taking 60 seconds to walk for recovery before your next sprint. 6-12 total sprint intervals is usually a very challenging workout for most people.

In addition, weight training naturally incorporates short bursts of exertion followed by recovery periods. High intensity interval training (varying between high and low intensity intervals on any piece of cardio equipment) is yet another training method that utilizes exertion and recovery periods. For example, an interval training session on the treadmill could look something like this:

Warm-up for 3-4 minutes at a fast walk or light jog

Interval 1 - run at 8.0 mi/hr for 1 minute
Interval 2 - walk at 4.0 mi/hr for 1.5 minutes
Interval 3 - run at 10.0 mi/hr for 1 minute
Interval 4 - walk at 4.0 mi/hr for 1.5 minutes

Repeat those 4 intervals 4 times for a very intense 20-minute workout.

Also, don't overlook other great ways to incorporate variable intensity cardio training by using a jump rope, a rowing machine, stairs running, or even outdoor hill sprints.

The take-away message from this article is to try to train your body at highly variable intensity rates for the majority of your workouts to get the most beneficial response in terms of heart health, fat loss, and muscle maintenance.

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IIFYM Sucks (here’s the proof)

Posted: 04 Sep 2013 08:27 AM PDT

IIFYM Sucks (here’s the proof)

There’s no higher thanks to say this…

The IIFYM (If It Fits Your Macros) approach to assembling muscle sucks, and for two crucial reasons.

#1: This principle offers the illusion to some those that all calories have identical result on your body â€" the largest non-sense of this Century.

#2: folks on this approach typically conclude that “moderation is key” (I’ll make a case for below).

Let’s address #1 initial.

I still hear folks from all backgrounds, all ages and every one countries telling Maine that calories area unit created equal. I call bullS%?$.

Of course, some of us can tell Maine that a calorie could be a calorie as a result of it’s simply a unit of energy. They’re right, however that’s not my purpose.

My purpose is that everybody reading this already is aware of that calories  from carbs don’t have identical result on your body as calories  from macromolecule. If not, take a “Nutrition 101” category before you scan on.

But what lots of individuals have a tough time acceptive is that different varieties of foods will have completely different|a special|a unique|a distinct} result on your body thanks to specific micro-nutrients or contaminants.

Let Maine drop some science here…

• Excess ketohexose (from honied carbs) disrupt your leptin secretion and ultimately impact androgen production
• GMO foods (virtually everywhere), gas and halide in water and pesticides area unit all shown to weaken your gut flora â€" conducive to excess inflammation in your body, slower recovery and smaller muscle gains
• Food, attention product, cosmetics, prescription drugs, pesticides, plastics, water and soil area unit all sources of endocrine disruptors (BPA, dioxins, etc.), that compound to disrupt sex hormone, androgen, thyroid perform and metabolism to some extent

(I’m positive you perceive that for the sake of simplicity, I didn’t include dozens of sources â€" shoot Maine AN email and I’ll show you the studies)

To this purpose, i believe it’s pretty safe to assume that your food and way decisions can all have an effect on your hormones and gains..

This leads USA to #2 â€" “moderation is key”.

I nearly fully trust that statement.

Eating natural, unprocessed, whole foods ninetieth of the time can provide you ninetieth of the results, and is arguably healthier for your mind than 100% restriction from any kind of treat or “bad” food.

The problem is â€" most of the foods in your electric refrigerator and storeroom area unit what I decision “fat storing” foods and you almost certainly don’t even understand it.

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Let Maine walk the speak and provides you examples:

1) Grass-fed Beef
Grass-fed beef is filled with the natural fat burner CLA, and contains a lot additional polyunsaturated fatty acid, vitamins and minerals than a budget supermarket kind.

But did you recognize that the term “grass-fed” isn't even regulated by the FDA?

That means that there’s an opening your costly beef has been fed grains in its last 3-4 months before ending up in your plate â€" nullifying any result the grass diet had within the initial place and leaving you with a meat that contains inflammatory omega-6 fatty acid that slow down your recovery any.

In the the reality regarding Fat Burning Foods, I reveal specifically what claims  guarantee that your beef is actually grass-fed.

2) rice

Everyone tells you that rice is healthier than white rice…

What they forgot to inform you is that rice â€" particularly rice â€" contains dangerous levels of arsenic. Yes, the foremost fashionable poison used in the center Age.

Don’t worry. nobody puts arsenic in your food by choice. Rice naturally absorbs arsenic from soil or water way more effectively than most plants, and stores it in its grains.

And since 1960, about 800,000 a lot of inorganic arsenic has been used in agriculture and industries.

Wait, it gets worse. The Environmental Protection Agency estimates that rice contributes to only Revolutionary Organization 17 November of your exposure to arsenic, which suggests you almost certainly affected by a nephrotoxic load that promotes fat storage and illness already.

To reduce arsenic content, rinse your rice completely and opt for imported rice over the one full-grown within the USA.

3) vegetable oil

This one isn't a fat-storing food, obviously… vegetable oil is incredibly healthy and one among the simplest you'll use to cook, but it gets costly in no time.

But the issue is â€" makers sell “raw” vegetable oil for the large price, once indeed raw vegetable oil doesn’t exist. Shipping containers accustomed ship the vegetable oil to the USA by ocean from the tropics reach temperatures of over 130°F.

The bottom line: If you’re paying additional for raw vegetable oil, you’re getting scammed.

4) Fish

A lot of bodybuilders suggest fish as a staple muscle-building food, and for lots of reasons. It’s usually low in calories, very simple to digest and contains a lot of essential polyunsaturated fatty acid.

But not all fish is formed equal.

Farmed fish you’ll realize in most supermarkets contain high levels of PCBs, dioxins, antibiotics and pesticides â€" that every one take a toll on your gut health and disrupt your androgen.

It additionally contains a minimum of three times less polyunsaturated fatty acid than its wild-caught counterpart â€" creating it really a awfully poor supply of essential fatty acids…

The obvious selection is to stay with wild-caught fish. The disgustful problem is â€" a recent study by the University of Washington Tacoma showed that four-hundredth of fish sold-out as “wild-caught” is in fact… farm-raised.

In the the reality regarding Fat Burning Foods, I reveal however you'll build  sure your costly wild-caught fish is really wild-caught and choked with anti-inflammatory polyunsaturated fatty acid.

In the meantime, if you'd like to learn more SHOCKING truths about “healthy” foods in your pantry, my buddy Nick Pineault gives you some awesome tips here:


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IIFYM Sucks (here’s the proof)

Posted: 04 Sep 2013 08:03 AM PDT

IIFYM Sucks (here’s the proof)

There’s no better way to say this…

The IIFYM (If It Fits Your Macros) approach to building muscle sucks, and for 2 critical reasons.

#1: This principle gives the illusion to some people that all calories have the same effect on your body â€" the biggest non-sense of this Century.

#2: People on this approach often conclude that “moderation is key” (I’ll explain below).

Let’s address #1 first.

I still hear people from all backgrounds, all ages and all countries telling me that calories are created equal. I call bullS%?$.

Of course, some folks will tell me that a calorie is a calorie because it’s just a unit of energy. They’re right, but that’s not my point.

My point is that everyone reading this already knows that calories  from carbs don’t have the same effect on your body as calories  from protein. If not, take a “Nutrition 101” class before you read on.

But what a lot of people have a hard time accepting is that different kinds of foods will also have a different effect on your body because of specific micro-nutrients or contaminants.

Let me drop some science here…

• Excess fructose (from sugary carbs) disrupt your leptin hormone and ultimately impact testosterone production
• GMO foods (virtually everywhere), chlorine and fluoride in tap water and pesticides are all shown to weaken your gut flora â€" contributing to excess inflammation in your body, slower recovery and smaller muscle gains
• Food, personal care products, cosmetics, pharmaceuticals, pesticides, plastics, water and soil are all sources of endocrine disruptors (BPA, dioxins, etc.), which compound to disrupt estrogen, androgen, thyroid function and metabolism to some degree
 

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(I’m sure you understand that for the sake of simplicity, I didn’t include dozens of sources â€" shoot me an email and I’ll show you the studies)

To this point, I think it’s pretty safe to assume that your food and lifestyle choices will all affect your hormones and gains..

This leads us to #2 â€" “moderation is key”.

I almost completely agree with that statement.

Eating natural, unprocessed, whole foods 90% of the time will give you 90% of the results, and is arguably healthier for your mind than 100% restriction from any form of treat or “bad” food.

The problem is â€" most of the foods in your fridge and pantry are what I call “fat storing” foods and you probably don’t even know it.

Let me walk the talk and give you examples:

1) Grass-fed Beef

Grass-fed beef is packed with the natural fat burner CLA, and contains a ton more omega-3, vitamins and minerals than the cheap supermarket kind.

But did you know that the term “grass-fed” is not even regulated by the FDA?

That means that there’s a possibility your expensive beef has been fed grains in its last 3-4 months before ending up in your plate â€" nullifying any effect the grass diet had in the first place and leaving you with a meat that contains inflammatory omega-6 that slow down your recovery further.

In the The Truth About Fat Burning Foods, I reveal exactly what claims  guarantee that your beef is really grass-fed.

2) Brown Rice

Everyone tells you that brown rice is healthier than white rice…

What they forgot to tell you is that rice â€" especially brown rice â€"contains dangerous levels of arsenic. Yes, the most popular poison used in the Middle Age.

Don’t worry. No one puts arsenic in your food on purpose. Rice naturally absorbs arsenic from soil or water much more effectively than most plants, and stores it in its grains.

And since 1960, about 800,000 tons of inorganic arsenic has been used in agriculture and industries.

Wait, it gets worse. The EPA estimates that rice contributes to only 17% of your exposure to arsenic, which means you probably affected by a toxic load that promotes fat storage and sickness already.

To reduce arsenic content, rinse your rice thoroughly and choose imported rice over the one grown in the US.

3) Coconut Oil

This one is NOT a fat-storing food, obviously… coconut oil is  incredibly healthy and one of the best you can use to cook, but it  gets expensive very fast.

But the thing is â€" manufacturers sell “raw” coconut oil for the big price, when in fact raw coconut oil doesn’t exist. Shipping containers used to ship the coconut oil to the US by sea from the tropics reach temperatures of over 130°F.

The bottom line: If you’re paying more for raw coconut oil, you’re getting scammed.

4) Fish

A lot of bodybuilders recommend fish as a staple muscle-building food, and for a lot of reasons. It’s generally low in calories, very easy to digest and contains a ton of essential omega-3.
But not all fish is created equal.

Farmed fish you’ll find in most supermarkets contain high levels of PCBs, dioxins, antibiotics and pesticides â€" that all take a toll on your gut health and disrupt your testosterone.

It also contains at least 3 times less omega-3 than its wild-caught counterpart â€" making it actually a very poor source of essential fatty acids…

The obvious choice is to stick with wild-caught fish. The revolting problem is â€" a recent study by the University of Washington Tacoma showed that 40% of fish sold as “wild-caught” is in fact…farm-raised.

In the The Truth About Fat Burning Foods, I reveal how you can make sure your expensive wild-caught fish is actually wild-caught and full of anti-inflammatory omega-3.

In the meantime, if you'd like to learn more SHOCKING truths about “healthy” foods in your pantry, my buddy Nick Pineault gives you some awesome tips here:


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Hypnotherapy for Tinnitus

Posted: 04 Sep 2013 06:26 AM PDT

Hypnotherapy for Tinnitus
Does psychotherapy extremely work? plenty of individuals can raise this question as a result of there's a good deal of mystery regarding it. typical physicians typically scorn at those that apply psychotherapy, however there square measure those that vouch regarding the positives. therefore whom does one believe?

Did you recognize that even the traditional life science is these days watching psychotherapy for a solution to varied illnesses? affirmative, that is true. Psychiatrists and psychologists square measure currently more and more turning to psychotherapy to achieve into the mind of the patient. they're getting down to believe that since the mind will management the body, it will be retrained to heal a condition. If nothing else, the mind will be trained to remain positive, and a positive angle typically helps in treatment.

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What regarding symptom - will psychotherapy facilitate Here?

Hypnotherapy will really work fine for symptom. {this is|this is often|this will be} as a result of a number of the noises someone hears can really be no noises the least bit. they're simply phantom sounds. it's really the perception of hearing them that bothers the person - there is completely no physical supply of those noises. therefore psychotherapy will work by training the mind to make sure that the person stops hearing them. The results can be superb extremely. it's been reportable that as several as five hundredth to seventy six of all symptom sufferers will get relief once simply many psychotherapy sessions. In some individuals, the noises depart utterly, and in others, the amount goes down significantly.

The Problem with psychotherapy is that the story regarding It

In reality, most of the people don't perceive psychotherapy, and the way it works. and that they square measure typically misguided by the psychological state sessions that square measure shown on tv. Here the healer can place someone to sleep and order him/her to try and do every kind of funny things. in fact nobody desires to be utterly susceptible to the whims of the healer, and thus, psychotherapy has ne'er extremely become a main-stream cure.

What extremely Happens in an exceedingly psychological state Session?

A real life psychological state session is way completely different than what's shown on tv. Here the healer can 1st place the person to a very relaxed state. Once this can be achieved, the healer chooses from many cures like regression medical care, ego state medical care and suggestive medical care. one session won't offer you the results, however take many of them, and you'll actually notice a distinction.

Hypnotherapy enhances self-consciousness, and this lets the person concentrate higher. this can be called the alpha state. once the person is in a position to realize this, he/she will recall the memory and retrain the brain to interrupt the memory loop of sound that causes the symptom sounds.

Never underestimate the ability of your brain. it's the power to dam off most of the items we have a tendency to see or hear everyday. If the brain could not try this, then we'd got to assess or analyze everything we have a tendency to see and listen to. however that is not what happens. this can be as a result of the brain prioritizes things and lets America get on with our daily lives.

Especially once symptom isn't directly associated with a risky physical health condition, exploitation the right manipulation, psychotherapy will decrease our awareness to the sounds of symptom.

Moreover, psychotherapy will considerably contribute to relaxation and distress the patient and there square measure some manifestations of symptom that square measure nearly directly associated with a prolong state of tension and stress or square measure intense by it.

Hypnotherapy will offer some relief from symptom. It will cut back or briefly create the sounds go. however bear in mind, the sound is simply a symbol. it's best that you simply try and cure the basis causes, rather than turning to symptomatic treatments like psychotherapy.

The only manner you'll ever get obviate your symptom permanently is by following the holistic approach to healing. By employing a three-dimensional treatment for symptom, we have a tendency to square measure effort all symptom anorectic factors and eliminating these triggering parts from the basis. this can be the sole path for permanent freedom from symptom.

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Hypnotherapy for Tinnitus

Posted: 04 Sep 2013 05:42 AM PDT

Hypnotherapy for Tinnitus


Does hypnotherapy really work? A lot of people will ask this question because there is a great deal of mystery about it. Conventional physicians often scorn at those who practice hypnotherapy, but there are those who vouch about the positives. So whom do you believe?

Did you know that even the conventional medical science is today looking at hypnotherapy for an answer to various illnesses? Yes, that's true. Psychiatrists and psychologists are now increasingly turning to hypnotherapy to reach into the mind of the patient. They are beginning to believe that since the mind can control the body, it can be retrained to heal a condition. If nothing else, the mind can be trained to stay positive, and a positive attitude often helps in treatment.

Tinnitus Cure Secrets ( Click Here For More Information )


What About Tinnitus - Can Hypnotherapy Help Here?

Hypnotherapy can actually work very well for tinnitus. This is because some of the noises a person hears can actually be no noises at all. They are just phantom sounds. It is actually the perception of hearing them that bothers the person - there's absolutely no physical source of these noises. So hypnotherapy can work by retraining the mind to ensure that the person stops hearing them. The results could be amazing really. It has been reported that as many as 50% to 76% of all tinnitus sufferers can get relief after just a few hypnotherapy sessions. In some people, the noises go away completely, and in others, the volume goes down considerably.

The Problem with Hypnotherapy Is the Myth about It

In reality, most people do not understand hypnotherapy, and how it works. And they are often misguided by the hypnosis sessions that are shown on television. Here the therapist will put a person to sleep and order him/her to do all kinds of funny things. Of course no one wants to be completely vulnerable to the whims of the therapist, and thus, hypnotherapy has never really become a main-stream cure.

What Really Happens In a Hypnosis Session?

A real life hypnosis session is much different than what is shown on television. Here the therapist will first put the person to a completely relaxed state. Once this is achieved, the therapist chooses from several cures such as regression therapy, ego state therapy and suggestive therapy. A single session might not give you the results, but take a few of them, and you can certainly notice a difference.

Hypnotherapy enhances self-consciousness, and this lets the person concentrate better. This is known as the alpha state. When the person is able to achieve this, he/she can recall the memory and retrain the brain to break the memory loop of sound that causes the tinnitus sounds.

Never underestimate the power of your brain. It has the ability to block off most of the things we see or hear everyday. If the brain couldn't do this, then we would have to evaluate or analyze everything we see and hear. But that's not what happens. This is because the brain prioritizes things and lets us get on with our daily lives.

Especially when tinnitus is not directly related to a risky physical health condition, using the correct manipulation, hypnotherapy can decrease our awareness to the sounds of tinnitus.

Moreover, hypnotherapy can significantly contribute to relaxation and distress the patient and there are some manifestations of tinnitus that are almost directly related to a prolong state of anxiety and stress or are intensified by it.

Hypnotherapy can provide some relief from tinnitus. It can reduce or temporarily make the sounds go. But remember, the sound is just a symptom. It is best that you try to cure the root causes, instead of turning to symptomatic treatments such as hypnotherapy.

The only way you could ever get rid of your tinnitus for good is by following the holistic approach to healing. By using a multidimensional treatment for tinnitus, we are tackling all tinnitus causative factors and eliminating these triggering elements from the root. This is the only path for permanent freedom from tinnitus.

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How To Use trade Plans For Your Next Woodwork Project

Posted: 04 Sep 2013 05:01 AM PDT

How To Use trade Plans For Your Next Woodwork Project

Have you finished any DIY trade comes before? If you have done it you are conscious of the actual fact that a decent construction needs some dedicated coming up with. If this is often your 1st strive it is important to form positive that you've got got a concept before you begin.

It does not ought to be troublesome to return up with arrange|an idea|a thought|a concept|an inspiration} for the project you are considering to start out with and also the project can rather more probably become as you wish it to be if you're taking yourself time to plan everything fastidiously before you begin mistreatment your tools.

One simple thanks to realize a decent arrange for your trade project is to seem on-line. cyber web is packed with attention-grabbing trade plans for DIY comes and you may be stunned by however simple it's to search out one that looks to be appropriate for you. you may in most cases be able to make a choice from a whole bunch, or perhaps thousands of trade plans and most of them square measure dedicated and straightforward to follow.

When you have determined what arrange you'd wish to use it is time to require a more in-depth examine it. you would possibly have to be compelled to search alittle on cyber web so as to find out additional regarding trade before you are able to begin. it is important that you simply have some information on the subject before you begin building one thing yourself, it's harder than you would possibly assume and it is easy to induce hurt unless you are careful.

If you have browse masses regarding DIY trade comes on cyber web however would really like to induce some answers to things that you simply assume is troublesome to know it's wise register for a member account on a forum relating to trade. you may shortly discover that there square measure many forums to decide on between and alternative members are able to assist you get a solution to each question you would possibly have.

The most vital issue once you are into trade is that the safety. you mostly have to be compelled to bear in mind of the actual fact that you simply will get hurt if you are not careful. this is often vital to stay in mind albeit you have completed several trade comes before. It's truly easier for skilled constructors to induce hurt since they're sometimes additional careless than beginners.

As you'll see you would like to try and do 3 things to start out with. realize a decent trade arrange, learn the maximum amount as you'll regarding trade and be as careful as you'll after you begin operating with the project.

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How to Handle Constipation

Posted: 04 Sep 2013 04:39 AM PDT

How to Handle Constipation

A case of constipation sometimes implies that you’ve had one or fewer bowel-movements in an exceedingly typical day. This may happen as a result of you’ve simply modified your diet from dangerous food to smart food. Your body has got to suits the various food, thus you have got to provide your body time to urge wont to it.

Another common cause for constipation is dehydration. If you don’t soak up the right quantity of water on a daily basis, you'll have hassle together with your colon being unable to push waste out.

What is thus dangerous concerning being bound is all that awful stuff that your body naturally gets eliminate stays in aspect you. This causes discomfort, fatigue, and even weight retention. This condition is sort of a buildup of poison within you: it will cause issues if you let it go too long. thus what are you able to do once you’re bound to correct the situation? I actually have some natural and healthy suggestions for this.
1 Drink a lot of water. you must be taking in concerning [*fr1] your body’s weight in fluid ounces of water. this implies that if you weigh 230 lbs, you must be drinking a hundred and fifteen ounces of water daily.

2 Use oilseed as AN additive to your meals. you'll be able to combine a tablespoon of it into your food to provide you a lot of fiber ( to assist get you moving) and Omega 3s in addition.

3 Raw food is vital. this implies you must eat one piece of recent fruit or raw veggies. Your system can have the benefit of the natural ingredients in raw foods that ar sometimes lost after they ar poached.

3 Begin your day with a tablespoon of juice. combine it in water and add some Cayenne. This mixture can stimulate your system and facilitate filter your colon.

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